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Mechanisms of resistance to third-generation EGFR tyrosine kinase inhibitors

Shuhang Wang,Yongping Song,Feifei Yan,Delong Liu

Frontiers of Medicine 2016, Volume 10, Issue 4,   Pages 383-388 doi: 10.1007/s11684-016-0488-1

Abstract: AZD9291 (osimertinib; Tagrisso) is the first and only FDA approved third-generation EGFR TKI for T790M-positiveThe mechanisms of resistance to third-generation inhibitors reported to date include the EGFRmechanisms of resistance to the EGFR TKIs, as well as the latest development of EAI045 as a fourth-generation

Keywords： EGFR     tyrosine kinase inhibitor     AZD9291     EAI045    

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Thoughts on the Development of Bridge Technology in China Review

Xuhong Zhou, Xigang Zhang

Engineering 2019, Volume 5, Issue 6,   Pages 1120-1130 doi: 10.1016/j.eng.2019.10.001

Abstract:

In the history of bridge engineering, demand has always been the primary” A new future is emerging for Chinese bridge engineering.As an important part of China’s transportation infrastructure, the bridge engineering industryAs a result, the development path of bridge engineering needs to be changed.This paper puts forward the idea of developing a third-generation bridge project that is characterized

Keywords： Chinese bridge engineering     Third-generation bridge engineering     Intelligent bridge     Science and technology    

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Targeting apoptosis to manage acquired resistance to third generation EGFR inhibitors

Frontiers of Medicine 2022, Volume 16, Issue 5,   Pages 701-713 doi: 10.1007/s11684-022-0951-0

Abstract: clinical challenge in lung cancer treatment is management of the inevitable acquired resistance to third-generationIt has been clearly shown that effective induction of apoptosis is a key mechanism for third generationapoptosis using various means promises an effective strategy for the management of acquired resistance to thirdgeneration EGFR-TKIs.

Keywords： acquired resistance     EGFR inhibitor     apoptosis     lung cancer    

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Strategic Study on the Development of Advanced Semiconductor Materials and Auxiliary Materials in China

Writing Group of Advanced Semiconductor Materials and Auxiliary Materials

Strategic Study of CAE 2020, Volume 22, Issue 5,   Pages 10-19 doi: 10.15302/J-SSCAE-2020.05.002

Abstract:

The rapid development of the third-generation semiconductor materialsequipment; and application demonstration projects for advanced semiconductor materials in the fifth-generationadvantageous resources, grasp the “More Than Moore” opportunity of to lay out the next-generation

Keywords： advanced semiconductor materials     auxiliary materials     third-generation semiconductor     2035    

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Effects of BTA2 as the third component on the charge carrier generation and recombination behavior of

Leijing Liu, Hao Zhang, Bo Xiao, Yang Liu, Bin Xu, Chen Wang, Shanpeng Wen, Erjun Zhou, Gang Chen, Chan Im, Wenjing Tian

Frontiers of Chemical Science and Engineering 2021, Volume 15, Issue 1,   Pages 127-137 doi: 10.1007/s11705-020-1936-7

Abstract: Effects of a benzotriazole (BTA)-based small molecule, BTA2, as the third component on the charge carriergeneration and recombination behavior of poly[[4,8-bis[(2-ethylhexyl)oxy]benzo[1,2-b:4,5-b']dithiophenesmall molecule with thiazolidine-2,4-dione, BTA, and indacenodithiophene as the terminal acceptor (A ), bridgeternary OSCs being lower than that of the binary OSCs, the optimized photon absorption and exciton generation

Keywords： third component     organic solar cells     charge carrier generation     charge carrier recombination     bimolecular    

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Analysis of genetic structure of three third-generation of successive meiogynogenetic families in Japanese

Hou Jilun,Li Chao,Wang Guixing,Zhang Xiaoyan,Sun Zhaohui,Wang Yufen,Jiang Xiufeng,Liu Haijin

Strategic Study of CAE 2014, Volume 16, Issue 9,   Pages 26-32

Abstract:

Three third-generation of successive meiogynogenetic families (Meio-G3

Keywords： Japanese flounder Paralichthys olivaceus     successive meiogynogenesis     homozygosity     inbred line    

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Third Generation Mobile Communication——The IP Oriented Application of Modern Wireless Communication Technology

Wu Hequan

Strategic Study of CAE 2000, Volume 2, Issue 8,   Pages 69-75

Abstract:

The article firstly reviews the evolution of the 1st generation (analogy) mobile communication systemand the 2nd generation (digital) mobile communication system, and predicts that deployment of mobileFollowing briefly addressing the second and half generation mobile communication system (2.5 GM) thatwill come to application soon, introduces the 3rd generation mobile communication (3 GM) for broadband

Keywords： mobile communication     third generation mobile communication     CDMA     TD - SCDMA    

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State-of-the-art of long-span bridge engineering in China

XIANG Haifan, GE Yaojun

Frontiers of Structural and Civil Engineering 2007, Volume 1, Issue 4,   Pages 379-388 doi: 10.1007/s11709-007-0051-x

Abstract: This paper introduces the state-of-the-art of longspan bridge engineering in China with emphases on recentlong-span bridge projects, bridge deck configuration and material, design codes of long-span bridges

Keywords： bridge engineering     state-of-the-art     long-span bridge     configuration     improvement    

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Practice and experience of engineering culture development in Sutong Bridge project

Yu Chunsheng,Yao Bei,Wang Qian

Strategic Study of CAE 2009, Volume 11, Issue 3,   Pages 92-96

Abstract: Engineering culture is an integration of project construction and engineering culture.However, engineering culture development enjoys its own particularity as a project is constructed onceThis paper gives affirmative opinion that engineering culture development in large-scale projects backsBridge project and after deepened analysis, proposes new thinking pattern of engineering culture developmentand systematic thinking pattern for engineering culture development in future large-scale projects.

Keywords： Sutong Bridge engineering culture     large-scale projects engineering culture development     systematic thinking    

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Concept and requirements of sustainable development in bridge engineering

Yaojun GE, Haifan XIANG

Frontiers of Structural and Civil Engineering 2011, Volume 5, Issue 4,   Pages 432-450 doi: 10.1007/s11709-011-0126-6

Abstract: single sustainable principle, two goals of sustainable development, three dimensions of sustainable engineeringThe safe reliability of bridges is first compared with the events of bridge failure in China and in theadaptability, lateral wind action on vehicles and its improvement are introduced regarding a sea-crossing bridgeChinese practice of using two double main span suspension bridges and a twin parallel deck cable-stayed bridge

Keywords： sustainable engineering     safe reliability     structural durability     functional adaptability     capacity extensibility    

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Dynamic analysis of composite beam subjected to harmonic moving load based on the third-order shear deformation

Mohammad Javad REZVANIL, Mohammad Hossein KARGARNOVIN, Davood YOUNESIAN

Frontiers of Mechanical Engineering 2011, Volume 6, Issue 4,   Pages 409-418 doi: 10.1007/s11465-011-0245-8

Abstract:

The response of an infinite Timoshenko beam subjected to a harmonic moving load based on the third-order

Keywords： timoshenko composite beam     pasternak viscoelastic foundation     third-order shear deformation theory (TSDT    

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Bridge engineering construction and technical innovation in the section between Beijing and Cangzhou

Du Jiajun

Strategic Study of CAE 2009, Volume 11, Issue 1,   Pages 22-25

Abstract:

According to the features of bridges in the section between Beijing and Cangzhou in Beijing-Shanghai high-speed railway, the construction and technical innovations which include special representative structure of bridges, control measures on settlement after the completion of bridges in the regional land subsidence area and assurance methods on high track regularity of ballastless track in 350 km/h speed are mainly introduced.

Keywords： high-speed railway     bridge engineering     construction     technical innovation    

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Early assessment of the safety and immunogenicity of a third dose (booster) of COVID-19 immunization

Frontiers of Medicine 2022, Volume 16, Issue 1,   Pages 93-101 doi: 10.1007/s11684-021-0914-x

Abstract: Here we report a pilot open-label trial of a third dose of BBIBP-CorV, an inactivated SARS-CoV-2 vaccineimmunity-associated cytokines and chemokines were also detected in the majority of participants after the thirdTogether, these results indicate that a third immunization schedule with either homologous or heterologous

Keywords： COVID-19     SARS-CoV-2     vaccine     immunization     booster immunization    

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Wind Resistance Safety of Marine Bridge Engineering and Corresponding Guarantee Countermeasures

Liao Haili , Li Mingshui , Zhou Qian

Strategic Study of CAE 2019, Volume 21, Issue 3,   Pages 12-17 doi: 10.15302/J-SSCAE-2019.03.012

Abstract:

Compared with that of the offshore and inland long-span bridges, the wind field of marine bridges will be more complicated, and their wind resistance safety will inevitably become tougher. This paper first analyzes the status quo of wind-resistance research of long-span bridges, and then focuses on the difficulties and technical problems regarding four aspects: wind field characteristics, wind-resistant design theories, countermeasures for wind-induced vibration, and windbreak technologies for driving safety. Based on these analyses, countermeasures for guaranteeing wind resistance safety of marine bridges are proposed.

Keywords： marine bridge engineering     wind resistance safety     typhoon     aerodynamic countermeasures    

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Lifecycle Management and Maintenance of Marine Bridge Engineering

Liu Muyu, Liang Lei, Wu Hao, Xu Gang, Li Qian

Strategic Study of CAE 2019, Volume 21, Issue 3,   Pages 25-30 doi: 10.15302/J-SSCAE-2019.03.013

Abstract:

Marine bridge engineering in China is continuously developing to themeasurement technology, inspection technology, and maintenance-management for the lifecycle of marine bridgeengineering.engineering, thereby providing technical support for the construction and operation safety of marinebridge engineering.

Keywords： marine bridge engineering     lifecycle management     health monitoring     automated inspection     engineering mapping    

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Title Author Date Type Operation

Mechanisms of resistance to third-generation EGFR tyrosine kinase inhibitors

Shuhang Wang,Yongping Song,Feifei Yan,Delong Liu

Journal Article

Thoughts on the Development of Bridge Technology in China

Xuhong Zhou, Xigang Zhang

Journal Article

Targeting apoptosis to manage acquired resistance to third generation EGFR inhibitors

Journal Article

Strategic Study on the Development of Advanced Semiconductor Materials and Auxiliary Materials in China

Writing Group of Advanced Semiconductor Materials and Auxiliary Materials

Journal Article

Effects of BTA2 as the third component on the charge carrier generation and recombination behavior of

Leijing Liu, Hao Zhang, Bo Xiao, Yang Liu, Bin Xu, Chen Wang, Shanpeng Wen, Erjun Zhou, Gang Chen, Chan Im, Wenjing Tian

Journal Article

Analysis of genetic structure of three third-generation of successive meiogynogenetic families in Japanese

Hou Jilun,Li Chao,Wang Guixing,Zhang Xiaoyan,Sun Zhaohui,Wang Yufen,Jiang Xiufeng,Liu Haijin

Journal Article

Third Generation Mobile Communication——The IP Oriented Application of Modern Wireless Communication Technology

Wu Hequan

Journal Article

State-of-the-art of long-span bridge engineering in China

XIANG Haifan, GE Yaojun

Journal Article

Practice and experience of engineering culture development in Sutong Bridge project

Yu Chunsheng,Yao Bei,Wang Qian

Journal Article

Concept and requirements of sustainable development in bridge engineering

Yaojun GE, Haifan XIANG

Journal Article

Dynamic analysis of composite beam subjected to harmonic moving load based on the third-order shear deformation

Mohammad Javad REZVANIL, Mohammad Hossein KARGARNOVIN, Davood YOUNESIAN

Journal Article

Bridge engineering construction and technical innovation in the section between Beijing and Cangzhou

Du Jiajun

Journal Article

Early assessment of the safety and immunogenicity of a third dose (booster) of COVID-19 immunization

Journal Article

Wind Resistance Safety of Marine Bridge Engineering and Corresponding Guarantee Countermeasures

Liao Haili , Li Mingshui , Zhou Qian

Journal Article

Lifecycle Management and Maintenance of Marine Bridge Engineering

Liu Muyu, Liang Lei, Wu Hao, Xu Gang, Li Qian

Journal Article